SKU: 16191511143

Tyemvers: Advanced European Botulinum Toxin Type A 10개 묶음 특가 (10-Pack Bundle Price): $270.00 (개당 $27.00)

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Description

Tyemvers: Advanced European Botulinum Toxin Type A 10개 묶음 특가 (10-Pack Bundle Price): $270.00 (개당 $27.00)10 . : 19 65 . : . : A (Clostridium Botulinum Toxin Type A) (Animal Free): (HSA) . . : . Introducing Tyemvers: The Next Generation in Aesthetic Neurotoxin Therapy Tyemvers (CKDB 501A), developed by CKD Bio, represents a significant advancement in botulinum toxin type A formulations. Engineered for purity, safety, and efficacy, Tyemvers offers a sophisticated solution for medical professionals seeking exceptional results in the temporary improvement of

종근당바이오의 차세대 비동물성 보툴리눔 톡신 안전성과 유효성을 입증한 프리미엄 톡신 제제를 10개 패키지 특별 할인가로 만나보세요.

✨ 효능 및 효과

  • 미간 주름의 일시적 개선: 만 19세 이상 만 65세 이하 성인의 눈썹주름근 및 눈살근 활동과 관련된 중등증 내지 중증의 심한 미간 주름을 일시적으로 개선합니다.

  • 정밀한 신경차단 효과: 아세틸콜린의 분비를 일시적으로 억제하여 근육을 이완시키고 주름을 부드럽게 펴줍니다.

🌿 성분 및 제품 특징

  • 유효 성분: 클로스트리디움 보툴리눔 독소 A형 (Clostridium Botulinum Toxin Type A)

  • 비동물성 안전 포뮬러 (Animal-Free): 사람혈청알부민(HSA) 대신 비동물성 부형제를 사용하여 혈액 유래 병원체 감염 위험을 최소화했습니다. 비건 성향의 환자나 동물성 성분에 민감한 분들에게 안심하고 권할 수 있습니다.

  • 독점 분양 균주 사용: 출처가 명확하고 투명한 유럽 소재 연구기관의 균주를 사용하여 신뢰성을 높였습니다.

Introducing Tyemvers®: The Next Generation in Aesthetic Neurotoxin Therapy

Tyemvers® (CKDB-501A), developed by CKD Bio, represents a significant advancement in botulinum toxin type A formulations. Engineered for purity, safety, and efficacy, Tyemvers® offers a sophisticated solution for medical professionals seeking exceptional results in the temporary improvement of moderate to severe glabellar lines. Our innovative approach, from strain selection to final formulation, prioritizes patient well-being and consistent clinical outcomes.

Key Characteristics & Advantages of Tyemvers®:

  • Exclusive European Strain (X58540): Tyemvers® is derived from the unique Clostridium botulinum strain X58540, sourced from a European institution and registered in the GenBank (National Library of Medicine, Accession No.: CP068960). This well-characterized strain forms the foundation of our product's consistent performance.

  • 100% Animal-Origin Free Manufacturing Process: Setting a new standard in safety, Tyemvers® is produced using a completely animal-origin free process. This includes the use of 1st and 2nd vegan media (plant-based) for culture, and the exclusion of animal-derived components such as casein, peptone, ribonucleases, and notably, Human Serum Albumin (HSA). This meticulous approach minimizes the risk of potential contamination and hypersensitivity reactions associated with animal-derived substances, including the potential for anaphylaxis linked to HSA.

  • Exceptional Purity & Potency: Tyemvers® boasts an outstanding purity profile of ≥ 99.9%, consisting of the 100% 19S (900kDa) toxin complex, as confirmed by HPLC analysis. This high level of purity contributes to its predictable efficacy and favorable safety profile.

    Potency of Tyemvers®3.0×107 units/mg

    This specific activity ensures a potent formulation designed for reliable results.

  • L-histidine as a Stabilizer: Tyemvers® utilizes L-histidine as a stabilizer, which also offers antioxidant effects. This contributes to the product's stability and quality throughout its shelf life. Sucrose is also included in the formulation.

  • Clinically Proven Efficacy for Glabellar Lines: Extensive Phase III clinical trials (Double-blinded, Randomized, Active Control Comparative, Multicenter-designed) have evaluated the safety and efficacy of Tyemvers® (CKDB-501A) for the improvement of moderate to severe glabellar lines, compared to Botox Inj.

    • Significant Improvement: Investigator-assessed improvement rates demonstrated strong efficacy. For instance, at Week 4, Tyemvers® showed an 80.69% improvement rate (proportion of subjects with ≥2-point improvement in glabellar line severity from baseline) compared to 70.83% for Botox®, proving non-inferiority.
    • Consistent results were observed across various assessment points and by subject assessment.
  • Favorable Safety & Tolerability Profile: The Phase III clinical trials confirmed an excellent safety profile for Tyemvers®.

    • Adverse drug reaction rates were statistically comparable to Botox®.
    • Importantly, no neutralizing antibody (ADA) formation was observed in subjects treated with Tyemvers® (0 out of 146 subjects).
    • The absence of HSA further enhances its safety profile by reducing the risk of associated allergic reactions.
  • Excellent Stability: Tyemvers® has demonstrated robust stability:

    • Room Temperature Stability: Stable for 12 months at 25 ± 2°C.
    • Accelerated Stability: Stable for 2 months under accelerated conditions at 40 ± 2°C. This offers convenience in storage and handling for practitioners.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 16191511143

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4.9 ★★★★★
Based on 1909 reviews
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Product Reviews
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Verified Purchase
Lexi
Birmingham, US
★★★★★ 4
Smaller than pictured but still a good choice for LG-XL dogs/power chewers!
Color: 3 PC-Beef-Red, Color: 3 PC-Beef-Red
Fantastic that these come in a 3 pack - I wish more chew toys did this! The base for these chew toys is pretty tough! The center & ends are hard enough to withstand both my bully mixes & my Irish wolfhound/Great Dane cross. They’re safe enough for even the largest power chewers! (With Supervision) my American Bully got the rubber spikes chewed off in under 20 minutes which is mildly disappointing but he’s a true powerhouse & master destroyer of all chews so I’m not that bent out of shape about it. I do wish they were as large as they appear in the ad pics but isn’t that the game we all play ordering offline anymore? 🤷🏻‍♀️ • Pro Tip: smear this toy in peanut butter (xylitol free!), wet food mixed into a slurry with water or bone broth + kibble/treats, yogurt, or even pumpkin puree and freeze for a few hours & relax while watching all the organic engagement your dog gets out of this toy!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 3, 2026
M
Verified Purchase
manuel rodriguez
Belleville, US
★★★★★ 5
My dog loves it
Color: 1 PC-Beef-Red, Color: 1 PC-Beef-Red
The bone arrived today and my dog loves it. He is a very aggressive chewer and destroyed almost all his toys so far, even toys that were advertised for aggressive chewers unfortunately didn't held out long, the longest so far was a stuffy we couldn't find anymore and that one lasted him a few weeks but everything else lasted him an hour up to a few days max, even bones don't last him long so we have our hopes set on this bone to satisfy his chewing needs. I will update my review later on sturdiness, since we just got it and I can't review that yet but so far he loves it he has been chewing on it non stop, he already managed to get very small pieces of as shown in picture but with a regular bone he would've already been much much further. The bone is only 10 bucks so the value for money you get based on my experience so far is amazing! But also for this I will come back later to touch upon more. The size is good, our boy is a medium sized dog and this bone was advertised for medium to large size dogs and I thinks the size is just right for our boy . And there is definitely a beef flavor on it you can smell it but it doesn't smell bad it's a nice smell and not very strong but when he is chewing on it you smell it. I would based on my experience so far definitely recommend this bone but also on this I will touch back upon later if it's worth it in the long run. So far a very happy dog and owners here. Edit on May 8th (original review was on March 11th) He still hasn't managed to destroy it it's the first (cgew)toy he hasn't managed to destroy yet which is very impressive since he managed to destroy the even most toughest things we got for him in a week tops and bones within 1, 2 days tops, so we are very happy and pleased with this bone and will definitely get more later. He still enjoys chewing on it and leaves our things mostly alone for some reason he just likes stealing my things and chew on it lol. So 2 months later still stand by recommending this when your dog loves to chew and destroys everything he puts his mouth on.
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Reviewed in the United States on March 11, 2026
J
Verified Purchase
Joy
Carnegie, US
★★★★★ 5
Extremely durable, dogs love them
Color: 2 PC-Beef-Red, Color: 2 PC-Beef-Red
I was looking for the toughest and most durable dog chew bone I could find and this is it. I have bought multiple other brands that claim to be very durable and tough for a very long time and this is the one for sure. The shower has described this phone accurately and it truly does last. I purchased this bone about 2 months ago. As you see from the photos attached, this is a very well made chew bone and my aggressive pitbulls can't tear it apart do they try. They never get tired of it and chewing it every single day for hours on and keeping them very occupied. I have two bones and three pitbulls that chew on it every day. It is so adorable and has an awesome flavor to it which I think entices them even more to want to chew on it. The durability and Lasting power is amazing to me with these tough chewers. I highly recommend this product to everyone out there. I will say only one negative and that is that the middle wraparound piece they were able to pull off but that is not a big deal because there is plenty of bone which was under that cover in the middle of the bone. There's a few mauled chips missing from the ends but the life of this bone is obviously going to be a long time which really surprised me. Give it a shot if you have heavy duty chewers and you will find how awesome this phone really is and it's durability and strength our second to none in my opinion.
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Reviewed in the United States on September 5, 2025
W
Verified Purchase
WhoFan69
Grantham, US
★★★★★ 5
My dog loves it.
Color: 1 PC-Beef-Red
My dog is a super aggressive chewer when it comes to toys. Anything that is soft he rips apart. This one has a wonderful squeaky sound that makes him happy and he enjoys the smell of it. This is a very strong material and definitely worth the price.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 10, 2026
J
Verified Purchase
jeniene
Bozeman, US
★★★★★ 4
Durable!
Color: 1 PC-Beef-Red
Alright, here's a product review for those Tough Dog Toys: Finally, a Toy That Survives My Monster! - Tough Dog Toys Review As the owner of a determined (and I mean determined) large breed chewer, finding toys that last longer than five minutes has been a constant and often frustrating quest. I've gone through countless plush toys ripped to shreds, rubber toys with chunks missing, and even some "indestructible" toys that met their demise far too quickly. That's why I was both hopeful and skeptical when I came across the Tough Dog Toys, designed specifically for aggressive chewers and large breeds. Let me tell you, these bone-shaped nylon toys are living up to their name. My power-chewing Labrador has been going at this thing for days now, and I'm genuinely impressed. Where other toys have succumbed to his relentless gnawing, the Tough Dog Toy has held its own. There are some minor teeth marks, as expected, but absolutely no significant damage, no pieces torn off, and no signs of imminent destruction. "Almost indestructible" might actually be an understatement! The design is simple but effective. The solid nylon construction feels incredibly durable, and the bone shape is easy for my dog to grip and maneuver. It's also a good size for a large breed – substantial enough that he can really get a good chew going without it disappearing in his mouth. What I appreciate most is the peace of mind this toy provides. I no longer have to constantly supervise playtime, fearing that he'll ingest pieces of a destroyed toy. This feels like a safe and long-lasting option for even the most enthusiastic chewers. Pros: * Truly durable – stands up to aggressive chewing from a large breed. * Solid nylon construction feels virtually indestructible. * Safe design with no small parts to break off. * Good size and shape for large dogs to grip and enjoy. * Provides long-lasting entertainment. Cons: * May show some teeth marks over time (though this hasn't compromised its integrity). * It's a fairly hard material, so dogs who prefer softer toys might not be as interested. Overall: If you're at your wit's end trying to find a toy that can withstand your aggressive chewing large breed dog, I highly recommend giving the Tough Dog Toys a try. This bone toy has proven to be the most durable option we've encountered, offering excellent value for money and, most importantly, a safe and engaging chewing experience for your furry friend. Five out of five paws!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2026

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