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Description
PE Mouse Anti-Human CD3 Antibody (S-R476)Product Specification Host Mouse Antigen CD3 Synonyms T cell surface glycoprotein CD3 epsilon chain; T cell surface antigen T3 Leu 4 epsilon chain; T3E; CD3E Location Cell membrane Accession P07766 Clone Number S R476 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation PE Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD3ε |
| Synonyms | T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; CD3E |
| Location | Cell membrane |
| Accession | P07766 |
| Clone Number | S-R476 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD3ε is a subunit of the CD3 complex, which is a critical component of the T-cell receptor (TCR) complex on T cells. Together with CD3γ, CD3δ, and CD3ζ, it forms the TCR-CD3 complex that plays a vital role in coupling antigen recognition to intracellular signaling pathways. This complex is essential for T cell activation, proliferation, and differentiation. CD3ε contains an extracellular immunoglobulin domain, a transmembrane region, and a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif (ITAM). Upon antigen recognition, the ITAMs in CD3ε are phosphorylated, initiating downstream signaling cascades that lead to T cell activation. Additionally, CD3ε interacts with other signaling molecules like Lck and Nck through its unique motifs, further modulating T cell responses. Its importance in T cell function makes CD3ε a target for immunotherapies, including cancer treatments and autoimmune disease management.
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4.2 ★★★★★
Based on 1849 reviews
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Product Reviews
★★★★★ 4
Interesting
Format: Kindle
This was a very captivating book once you got into it thoroughly. But the third person perspective was a bit hard to get used to. But as you got into it and followed the different characters, it was interesting and filled with intrigue, conflict and forbidden love.
I can’t wait to read the next one and to complete the series.
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Reviewed in the United States on November 12, 2022
★★★★★ 5
LOVED THIS STORY!
Format: Kindle
I never wite reviews, but this book was too good for me to NOT give props and let others readers know it's such a good read. They need to make movies of this one and I can't wait until the next book comes out. The story building was so good and I loved that the main character wasn't a silly useless princess or something. Shes intelligent, strong, and loves her friends. The description of the characters is really good also and its such a good plot. Not your average paranormal romance novel of some princess or the girl working at a diner. LOL! I'm totally team Rykan for her! Fingers crossed for the next book and October 31st can't come soon enough.
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Reviewed in the United States on September 15, 2023
★★★★★ 4
Imperfect characters
Format: Kindle
4.5 stars ⭐
I don't really understand the harsh criticism in some of these reviews (Goodreads). I rarely write reviews myself, but I think this book deserves it.
Look, it absolutely has its issues. I wasn't feeling it in the beginning -- the first few chapters were all tell and no show, literally just telling us all this background in a few paragraphs rather than feeding us bits and pieces at a time. The writing significantly improves after a few chapters, though. And I didn't catch any spelling or grammatical typos often found in new, self published books.
After the rough start, I absolutely flew through the rest of the book and couldn't put it down. Seriously stayed up until 2am with it. So I also don't agree with comments calling it boring. Definitely did not bore me. I thought it ticked all the right boxes: romance, fantasy, a magic system, tragedy, fate, character growth.
A lot of the poor reviews I'm seeing are in regards to the FMC's character. Personally, I like flawed characters and think it's more realistic than reading the POV of someone who always makes the right decisions, is always honest, is always selfless, etc. Humans aren't like that. Readers love when male leads are morally grey, but God forbid a woman isn't perfect.
So I like flawed characters and I like a little bit of tragedy, which the author provides. Ends on a cliffhanger, and I can't wait to read the sequel next month. I really want to learn more about Malachi.
All in all, not a bad start from this author. Give it a chance.
SOMEWHAT SPOILERY:
I LOVE the concept of fated mates that kind of hate each other. Most books with the fated mates trope allow the characters to immediately fall for each other and get together relatively easily. But this is way more interesting ;)
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Reviewed in the United States on October 1, 2023
★★★★★ 5
what just happened
Format: Kindle
I’m not gonna lie. This story had me from the beginning. It’s something about a girl running from an obsessive stalker that happens to be set in a fantasy realm. This story had everything you could want in a great plot. I mean intrigue, politics, betrayal, murder, witches, shades, fairies, shifter, etc. My heart grieved for Dahlia and everything she went through and honestly i don’t know who to root for in this story as all the males are morally gray which I love. All have a hint of evil. Book up this book and you won’t be disappointed. Soo ready for the next book.
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Reviewed in the United States on September 18, 2023
★★★★★ 3
Beta readers, please
Format: Kindle
I haven’t written a review in a while but this one motivated me to because it had potential and with some honest beta readers correcting its nonsense, it could have been pretty good. The writing is awkward at times and the world building was slow and one dimensional until around half way through and then it got much better. The main issues are with the characters, dialogue and plot. The FMC swings from stupidly trusting her “ friends” even when she is repeatedly betrayed to hating those who betrayed her to seemingly forgetting she hated them. It’s a whirlwind that reeks of adolescent drama and doesn’t fit the plot the author was trying, I think, to execute. The ridiculous decisions the character makes are so obviously made to move the plot in the direction the author was trying to go and was so basic in plot writing it was at times like reading a teenager’s writing project. It was hard to connect to the main character and hard to like any of the others. The author has potential but it was not met in this book. I will not be reading the next and really had to push through to even finish this one.
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Reviewed in the United States on December 4, 2023
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